Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Application of 99mTc-DTPA radiotracer in Persian cat renal scintigraphy

Gholamreza Assadnassab¹ , Shahram Dabiri Oskoei²

¹Department of Clinical Science, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University; ²Department of Nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

For correspondence:- Gholamreza Assadnassab Email: assadnassabgh@iaut.ac.ir Tel:+989144121145

Received: 4 March 2015 Accepted: 28 July 2015 Published: 29 September 2015

Citation: Assadnassab G, Oskoei SD. Application of 99mTc-DTPA radiotracer in Persian cat renal scintigraphy. Trop J Pharm Res 2015; 14(9):1691-1694 doi: 10.4314/tjpr.v14i9.21

© 2015 The authors.
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Abstract

Purpose: To evaluate the suitability of 99mTc-DTPA as a radiotracer in Persian cat's renal scintigraphy.

Methods: twelve adult healthy Persian cats were selected. For scintigraphy, the animals were anesthetized and 99mTC-DTPA was injected via the femoral vein as a bolus at a dose of 1.5 mCi. Immediately after intravenous injection of radiotracer, scintigraphic operation was conducted on the renal organ. dministration of the radioisotope and accumulation of radioisotope in the tissues was monitored by specific imaging theemanating

Results: Distinct scintigraphic scans were obtained using 99mTC-DTPA. Visual comparison of the scans indicates that there was no significant difference in the accumulation of radiotracer. In dynamic scans, symmetric and concurrent distribution of 99mTc-DTPA in the kidney was observed.

Conclusion: The results show that the radiopharmaceutical 99mTc-DTPA is suitable for use in Persian cat's renal scintigraphy, and this makes it potentially useful in research and clinical practice.

Keywords: Kidney, Persian cat, Radiotracer, Scintigraphy, Technetium-99m diethylene triamine pentacaetic acid (99mTc-DTPA)